Grease a 4-quart slow cooker well.
Boil the macaroni 2 minutes less than the package directions (5 to 6 minutes). Drain; do not rinse.
Whisk the evaporated milk, whole milk, eggs, dry mustard, garlic powder, paprika, salt, and pepper.
Put the hot pasta in the slow cooker. Stir in the melted butter and 3 cups of the cheese, then pour in the milk mixture and stir.
Cover and cook on LOW 2 to 2 1/2 hours, stirring at 1 hour and again at 2 hours, until the edges are set and the center is creamy.
Stir in the remaining 1 cup of cheese, cover, and rest 10 minutes before serving.